Alexandre Xavier

Dr. Alexandre Xavier is a Postdoctoral Research Fellow at the University of Newcastle's School of Biomedical Sciences and Pharmacy, affiliated with the College of Health, Medicine and Wellbeing. His research focuses on epigenetic mechanisms underlying neurological and genetic diseases, particularly multiple sclerosis (MS) and colorectal cancer. He leads projects analyzing DNA methylation patterns, genetic risk factors, and biomarkers for disease progression and therapeutic response.

Key areas of investigation include the interplay between epigenetic changes, environmental factors, and genetic predisposition in MS pathogenesis. He also explores cancer genetics through whole exome sequencing to identify pathogenic variants in familial colorectal cancer cases. His work contributes to biomarker development and precision medicine strategies.

Recent studies highlight his contributions to understanding cladribine efficacy in MS via epigenetic profiling and identifying HLA-DRB1*15:01 interactions influencing monocyte profiles. Collaborative projects like the Ausimmune study and CLOBAS trial underscore his commitment to translational research.

Dr. Xavier's funding includes MS Australia grants supporting his work on epigenetic signatures for MS diagnosis and treatment monitoring. His research integrates molecular biology, immunology, and epidemiological approaches to tackle complex diseases' genetic and environmental dimensions.