Alexander Roesch

Prof. Dr. Alexander Roesch is a Professor at the University of Duisburg-Essen's Medical Faculty, leading the Tumor Heterogeneity & Plasticity Group within the Clinic for Dermatology. His research focuses on melanoma biology, therapy resistance mechanisms, and liquid biopsy technologies. He coordinates the Clinical Research Unit CRU/KFO 337 (PhenoTImE) and participates in the EU Horizon 2020 MELGEN training program.

• Education: No explicit details provided; inferred expertise from publications and clinical roles.

Research interests include tumor cell state plasticity, epigenetic regulation (e.g., KDM5B), and non-invasive liquid biopsy platforms for real-time monitoring. His work bridges basic science and clinical translation, with contributions to understanding therapy resistance via phenotypic switching and metabolic reprogramming. Key projects involve multiplexed imaging (CODEX™), mass spectrometry, and CRISPR-based approaches.

Publications highlight advancements in melanoma therapy optimization, biomarker discovery (e.g., ctDNA), and immunotherapy efficacy prediction. Recent work emphasizes IL-17's role in checkpoint inhibitor response and spatial proteomics in tumor immunity.

• Grants/Awards: DFG-funded CRU/KFO 337 extension (€4M), EU Horizon 2020 MELGEN funding.
• Labs/Teams: Tumor Heterogeneity & Plasticity Group, collaboration with European Liquid Biopsy Society (ELBS).