Alexander Garthe

Dr. Alexander Garthe is a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Dresden, Germany, focusing on translational neuroscience to bridge preclinical animal models and clinical assessments in neurodegenerative disorders.

His research centers on spatial learning deficits as early biomarkers of Alzheimer's disease. Key initiatives include:

• Developing the Dresden Spatial Navigation Task (DSNT), a virtual reality adaptation of the Morris water maze for cross-species analysis
• Investigating region-specific neurotransmitter dynamics during spatial learning using structural equation modeling
• Applying high-dimensional Markov chains to quantify individual spatial knowledge acquisition

His group leverages computational modeling and virtual reality to identify sensitive cognitive markers for early dementia detection while decoding neural mechanisms underlying spatial navigation deficits.