Alessandro De Simone

Alessandro De Simone is an Assistant Professor in the Department of Genetics and Evolution at the University of Geneva. His research group investigates the physical principles of vertebrate regeneration using zebrafish scales as a primary model system, focusing on how cells coordinate growth and patterning during tissue repair.

Research interests center on the integration of biochemical signaling and mechanical forces in regeneration. Key areas include:

• Erk activity waves controlling tissue size/shape
• Mechano-chemical coupling in cell proliferation
• Coordination of bone formation with cell growth
• Quantitative live imaging of signaling dynamics
• Computational modeling of morphogenesis

Publications demonstrate a strong interdisciplinary focus, with recurring themes in regeneration signaling waves, live imaging of developmental processes, and mathematical modeling of tissue dynamics. Recent work emphasizes Erk/JNK wave propagation in zebrafish models and stem cell-based approaches to human development.

Scientific awards and recognitions include:

• SNSF Eccellenza Professorial Fellowship (PCEFP3_202776)
• ERC Starting Grant (Gradients, waves and nematics: quantitative perspectives on regeneration)

De Simone advises PhD students and oversees research projects on regeneration mechanisms. Current PhD advisees include Konrad Marx, Coline Coudeville, and Oriane Foussadier. External funding supports investigations into signaling dynamics and tissue patterning.

The laboratory, located in Sciences III building, includes postdoctoral researchers, PhD students, and technical staff specializing in live imaging, molecular biology, and zebrafish genetics. Team members collaborate on projects bridging experimental biology with computational approaches.