Alejandro R. Chade

Alejandro R. Chade, MD, is a Professor of Medical Pharmacology and Physiology at the University of Missouri School of Medicine and a NextGen Precision Health Investigator. His research focuses on cardiovascular and renal physiologic imaging, microcirculatory function, and mechanisms of renal and cardiac disease. Dr. Chade’s laboratory develops translational swine models of chronic kidney disease (CKD) and hypertension, leveraging advanced imaging techniques such as multi-detector CT and echocardiography to study renal and cardiac function. His work also explores novel therapeutic strategies targeting the renal and cardiac microcirculation to mitigate inflammation and improve organ function.

Education: MD from Universidad Nacional de Cuyo (1996), Cardiology Residency and Fellowship at Hospital Lagomaggiore (2001), and postdoctoral training at the Mayo Clinic (2005). He has held roles at the University of Mississippi Medical Center before joining the University of Missouri.

Research Interests include mechanisms linking CKD to cardiovascular disease, imaging-based diagnostics, and drug delivery systems for targeted therapies. His lab investigates macrophage polarization, NF-kB signaling pathways, and the role of mitochondrial DNA in renal injury.

• Key Awards: American Heart Association Established Investigator Award, Mid-Career Award, and numerous travel and recognition awards for hypertension and renal research.
• Publications focus on swine models, renal-cardiac crosstalk, and VEGF-based therapies, with high-impact contributions to American Journal of Physiology and Hypertension.
• Labs/Teams: Leads the NextGen Precision Health Initiative, collaborating on translational research to bridge basic science and clinical applications.