Alan R. Shuldiner

Alan R. Shuldiner, MD, is the John L. Whitehurst Professor of Medicine at the University of Maryland School of Medicine and serves concurrently as Associate Dean for Personalized & Genomic Medicine, Director of the Clinical Translation Sciences Institute, Co-Director of the University of Maryland Clinical and Translational Research Institute (CTSI), and Head of the Division of Endocrinology, Diabetes and Nutrition. He also holds a secondary appointment in Physiology and serves as Vice-President and Co-Head of the Regeneron Genetics Center.

Education & Training

• Lafayette College — BA, Chemistry, 1979
• Harvard Medical School — MD, 1984
• Columbia-Presbyterian Hospital — Residency in Internal Medicine, 1986
• NIH/NIDDK — Fellowship in Endocrinology & Metabolism, 1990

Research Focus

Dr. Shuldiner is an international leader in the genetics of age-related diseases, with major contributions to understanding the molecular basis of type 2 diabetes, obesity, osteoporosis, and cardiovascular disease. His pioneering work in the Old Order Amish—a genetically homogeneous founder population—has uncovered key causal variants including the first human APOC3 null mutation and loss-of-function alleles in CYP2C19 that modulate clopidogrel response. These discoveries have advanced precision medicine, directly influencing FDA drug-labeling and clinical genetic testing guidelines.

His multidisciplinary team integrates state-of-the-art molecular genetics, large-scale genomics, statistical modeling, and epidemiology to translate genomic findings into actionable clinical tools. More recently, his collaborative efforts at the Regeneron Genetics Center leverage exome and genome sequencing of >600,000 individuals to identify novel therapeutic targets for metabolic and cardiovascular disorders.

Awards & Honors

• Mallinckrodt Foundation Scholar Award (1991-1993)
• AFAR Award for Biomedical Research (1993-1995)
• Paul Beeson Physician Faculty Scholar Award (1995)
• Ellison Medical Foundation Senior Scholar Award (2000)
• Fellow, American College of Physicians (2003)
• Mary Betty Stevens Award for Excellence in Clinical Research (2003)
• Herman O. Mosenthal Memorial Award, ADA (2005)
• Founders Day Researcher of the Year, University of Maryland Baltimore (2005)
• Star of Hope Award, JDRF Maryland Chapter (2012)
• Wilkinson Lectureship, Vanderbilt University (2016)

Training & Mentorship

Dr. Shuldiner has trained >80 scholars: 20 predoctoral students, 30 post-doctoral fellows, and 32 junior faculty, most of whom now hold successful academic positions. He was Principal Investigator of the UM-NIH Roadmap K12 Multidisciplinary Clinical Scholars Program, which supported >20 junior investigators in patient-oriented research.

Laboratory & Core Facilities

He directs the University of Maryland Personalized and Genomic Medicine Program and leads a large, multi-disciplinary research team embedded within the CTSI. The laboratory utilizes cutting-edge molecular, statistical, and epidemiological resources to advance genomic discovery and clinical translation.