Alan Dombkowski

Alan Dombkowski is a Professor of Pediatrics at Wayne State University School of Medicine, specializing in molecular mechanisms of neurological disorders through genomic and bioinformatic approaches.

• Key research focus: Epileptogenic potential of cortical tubers in Tuberous Sclerosis Complex (TSC)
• Methods: Next-gen sequencing, microarrays, proteomics, and epigenetic analysis of human brain tissue
• Current projects funded by federal grants examining microRNA regulation and therapeutic targets in epilepsy

Recent publications span:

• 2024: Cisplatin-induced cochlear synaptic proteomics
• 2023: Multi-omic biomarkers for prostate cancer aggressiveness
• 2021: Exosomal miRNA in TSC epilepsy
• 2018: Neuroinflammatory mechanisms in pediatric epilepsy

Collaborations include Harry Chugani (neuroimaging), Diane Chugani (neurochemistry), Eishi Asano (epileptology), and Paul Stemmer (molecular pharmacology).