Aedin Culhane

Aedin Culhane is a Professor of Biomedical Sciences (Cancer Genomics) at the University of Limerick School of Medicine. She leads the Limerick Digital Cancer Research Centre and co-leads the all-island eHealth-Hub for Cancer. Her expertise spans computational oncology, multi-omics data integration, and clinical bioinformatics, with over 20 years of experience in cancer genomics, including roles at the Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health in Boston, USA.

Education:

• PhD in Cloning and Characterisation of Interleukin-18 in rat brain, University of Manchester

Research Interests: Cancer computational genomics, digital health, single-cell genomics, spatial biology, tumor microenvironment, immune-oncology, and open science initiatives like Bioconductor and OHDSI. She focuses on algorithm development for integrative multi-omics data analysis and translational oncology, including tumor drug resistance mechanisms and CAR-T cell therapies.

Recent Article Trends: Her work emphasizes spatial profiling of cancer microenvironments, CAR-T cell engineering, and genomic minimal datasets for precision oncology. Key themes include immune response modulation, Myc activity regulation in treatment persistence, and CRISPR-based functional genomics.

Awards:

• Young European Research Universities Network (YERUN) Open Science Award (2023)
• Bioconductor Community Award (2021)

Grants & Collaborations: Leads the €730,000 Chan Zuckerberg Initiative-funded eHealth-Hub for Cancer. Active in the 1+ Million Genomes Program and Genomic Data Infrastructure (GDI) projects. Collaborates internationally in spatial profiling and multi-omics integration through hackathons and open-source initiatives.

Labs & Teams: Directs the Limerick Digital Cancer Research Centre, a hub for AI-driven cancer research and translational genomics. Engages with global networks like the Human Cell Atlas and National Spatial Profiling Platform.