Adrian Whitty

Adrian Whitty is an Associate Professor in the Department of Biology at Boston University. His research focuses on protein-protein and protein-ligand recognition, particularly in developing mechanistic understandings of growth factor receptor activation and advancing drug discovery for protein-protein interaction inhibition.

• Education: B.Sc. (Honors) in Chemistry from King’s College, University of London (1985); Ph.D. in Organic Chemistry from the University of Illinois at Chicago (1991); Postdoctoral Research Fellow at Brandeis University's Biochemistry Department (1990-93).

His work integrates biochemical and cell-based assays using advanced technologies like FRET, Time-Resolved Fluorescence, and Surface Plasmon Resonance (Biacore 3000). He collaborates with computational chemists, organic synthesis experts, X-ray crystallographers, and biologists to develop novel approaches for designing small molecule inhibitors of protein-protein interactions.

Recent publications highlight trends in machine learning applications for molecular scientists, structural analysis of enzyme mechanisms, macrocycle-based drug design, and quantitative studies of protein interaction energetics. His lab emphasizes rigorous hypothesis-driven experimental design, preparing students for careers in academia or industry.

Advisory and leadership roles include membership in The Protein Society (2008-present), the American Society of Biochemistry and Molecular Biology (ASBMB) Governing Council (2007-present), and founding roles in the Council for Systems Biology in Boston (CSB2) and the Institute for Chemical Biology and Drug Discovery at SUNY Stony Brook.

His laboratory is equipped with state-of-the-art facilities for fluorescence, analytical ultracentrifugation (AUC), dynamic light scattering (DLS), isothermal titration calorimetry (ITC), and tissue culture, supporting diverse techniques including flow cytometry and reaction pathway modeling with Mathematica and MATLAB.