Adrian Shimpi

Dr. Adrian Shimpi is a Research Fellow in the Department of Biomedical Engineering at the University of Virginia. He is part of Kristen Naegle’s lab, focusing on molecular networks underlying cellular heterogeneity. His work integrates computational approaches with experimental methods to study phosphotyrosine signaling and how microenvironmental changes influence cell phenotypes. He holds a Ph.D. in Biomedical Engineering from Cornell University (2023) and a B.S. in Bioengineering from the University of Utah (2016).

• Education:
• Ph.D., Biomedical Engineering, Cornell University, 2023
• B.S., Bioengineering, University of Utah, 2016

His research interests span systems biology, cancer biology, and extracellular matrix interactions. He investigates how molecular ecosystems in different cell states relate to disease progression, particularly in cancer. His work bridges computational modeling and experimental validation to understand tumor heterogeneity and metastasis.

His recent articles highlight advancements in understanding tumor invasion mechanisms, phosphoproteomic changes, and the role of mineralization in cancer progression. He has been recognized with the NSF Graduate Research Fellowship, reflecting his impactful contributions to biomedical engineering.

Adrian’s lab focuses on engineered ECM models and their application to studying tumor heterogeneity, emphasizing translational research for clinical applications.