Adam Siepel

Professor Adam Siepel is a prominent computational biologist at Cold Spring Harbor Laboratory (CSHL), where he has directed the Simons Center for Quantitative Biology since 2014. Holding a Ph.D. in Computer Science from UC Santa Cruz (2005), Siepel bridges computer science, statistics, and genetics to decode evolutionary patterns in genomic data.

• Key affiliations: CSHL (2014-present), Cornell University (2006-2014), National Center for Genome Resources (1996-2001)

Research Focus:
His work centers on developing mathematical models and computational methods to analyze genomic evolution. Siepel's lab explores molecular evolution, transcriptional regulation, and population genetics, with applications spanning cancer, plant breeding, and human disease.

Recent Research Trends:
His team has published extensively on transcription elongation dynamics, ancient human evolution, maize domestication, and cancer metastasis mapping. Articles highlight integration of nascent RNA sequencing, machine learning, and ancestral recombination graphs.

Scientific Recognition:

• Guggenheim Fellowship (2012-2013)
• Sloan Research Fellowship (2009-2011)
• Packard Fellowship (2007)
• NSF CAREER Award (2007)

Mentorship & Collaboration:
Mentored over 20 graduate and postdoctoral researchers, including Ziyi Mo and Armin Scheben. Collaborates with experimentalists in cancer, neuroscience, and plant biology.

Lab Overview:
The Siepel Lab unites mathematicians, physicists, and biologists to tackle interdisciplinary problems. Current projects include modeling transcriptional equilibrium, tracking cancer evolution, and analyzing primate genomic constraints.