Adam Orr

Adam Orr is an Assistant Professor of Research in Neuroscience at the Brain and Mind Research Institute, part of Weill Cornell Medical College. His work bridges neuroimmunology, mitochondrial biology, and neurodegenerative diseases.

Research Interests: Orr investigates the role of astrocytes in neurodegeneration, focusing on mitochondrial reactive oxygen species (ROS) generation, TDP-43 pathology, and immunometabolic disruptions. His studies span Alzheimer's disease, Parkinson's disease, and Huntington's disease, emphasizing mechanisms like neuroinflammation and protein misfolding.

Publication Trends: His recent articles (2022-2025) highlight cross-disease proteomics, astrocytic stress granule formation, and sex-dimorphic effects in hippocampal function. These works integrate multi-omics approaches with mechanistic studies of ROS and metabolic dysregulation.

Scientific Awards:

• Co-Investigator, National Institute on Aging (2024-2026): Uncovering Dementia-Related Lipid Alterations and Mechanisms in Astrocytes
• Co-Investigator, National Institute on Aging (2020-2026): Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and Neuroinflammation
• Co-Investigator, National Institute of Neurological Disorders & Stroke (2020-2025): Defining the Effects of Astrocytic TDP-43 Dysregulation on Hippocampal Function