Abderrahim Oussalah

Abderrahim Oussalah is a Professor and MD at the University of Lorraine, Faculty of Medicine, based at Campus Brabois Santé in Vandoeuvre-lès-Nancy. His research focuses on inborn errors of metabolism, particularly cobalamin (vitamin B12) metabolism, epigenetics, and biomarker discovery for liver/kidney disorders and genetic diseases.

His research interests center on inborn errors of metabolism with emphasis on cobalamin metabolism disorders (cblC, cblG), epigenetic mechanisms in diseases like hepatocellular carcinoma, and biomarker development for conditions including cirrhosis, sepsis, and inflammatory bowel disease. His work integrates multi-omics approaches to correlate molecular findings with clinical phenotypes.

Recent publications reveal strong trends in genetic diagnostics (exome sequencing for Mendelian disorders), epigenetic signatures (DNA methylation for cancer detection), and clinical biomarker validation (pro-adrenomedullin for bacterial peritonitis, calprotectin for ulcerative colitis). His research bridges basic science with clinical applications, particularly in rare metabolic diseases.

Scientific contributions include:

• Discovery of epi-cblC disorder (transgenerational epimutation)
• Development of epigenomic signatures for hepatocellular carcinoma
• Validation of novel biomarkers for sepsis and renal dysfunction in cirrhosis
• Expansion of genetic spectrum for Tatton-Brown-Rahman syndrome

His collaborative work involves multi-institutional studies on vitamin B12 metabolism, with technical platforms including functional genomics, bioinformatics, and specialized cell culture. Current projects focus on epigenome-wide alterations in metabolic disorders and translation of biomarkers to clinical practice.